Humanity Incorporated
Relay by Humanity Incorporated

Statins for primary prevention: the published evidence

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What the published evidence actually says about statins in people who have not had a cardiovascular event: the benefit, the harms in absolute terms, what is contested, and how old each finding is. Assembled by Humanity Incorporated from named papers, each cited with its DOI.

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Assembled by Humanity Incorporated from published papers retrieved through PubMed. It is not a guideline, not a recommendation, and no clinician has reviewed the summaries against the papers. Every passage names its source and carries a DOI, so check the paper rather than trusting the summary. It cannot tell anyone whether to start, continue or stop a statin: that rests with the prescriber, the patient, and the guidance that applies to them.

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Once Relay is in your assistant, it can consult this guidance when you ask about something it covers, and the answer comes back with the source, where the guidance stops, and who to speak to. It does not replace judgement, procedures or responsible people.

Topics covered

Treatment evidence Absolute risk Evidence quality Shared decision making

What is in it (3 documents)
  • Taylor et al, Statins for the primary prevention of cardiovascular disease, Cochrane Database of Systematic Reviews 2013 2013 (searches to January 2012) Advisory Our wording, check the source read the source
  • Cai et al, Associations between statins and adverse events in primary prevention of cardiovascular disease, BMJ 2021 2021 (searches to August 2020) Advisory Our wording, check the source read the source
  • Cholesterol Treatment Trialists Collaboration, Effect of statin therapy on muscle symptoms, Lancet 2022 2022 Advisory Our wording, check the source read the source

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